A Japanese circulation ritual for heart health, energy & longevity support.

Nattokinase Blend 6,000 FU is Crane Wellness’ signature cardiovascular support supplement, inspired by traditional Japanese natto and backed by modern clinical research on circulation, blood pressure, and arterial health. PMC+1

This guide walks you through exactly what it is, how it works, who it’s for, how to take it, and how to pair it with your daily wellness ritual.

What Is Nattokinase Blend?

Nattokinase Blend 6,000 FU is a Japanese-formulated supplement designed to support:

• Healthy blood flow and circulation

• Cardiovascular and arterial health

• Blood pressure within the normal range

• Energy, stamina, and overall longevity habits

Each serving (2 capsules) delivers:

• Nattokinase – 6,000 FU (fibrinolytic enzyme from fermented natto)

• GABA – supports relaxation and healthy stress response

• Aomori Garlic Extract – traditional vascular & immune support

• Okinawa Moromi Vinegar Extract – metabolic & circulatory support

All developed and manufactured in Japan, drawing on decades of natto and nattokinase research.

Who Is Nattokinase Blend For?

This blend is designed for adults who want proactive circulation and heart health support, especially if you:

• Spend long hours sitting (desk work, driving, travel)

• Have cold hands and feet or feel “sluggish” circulation

• Are focused on healthy blood pressure and arteries as you age

• Have a family history of heart or vascular issues (and want lifestyle support)

• Are working on a longevity routine and want to support healthy blood flow, mobility, and resilience

Important: Nattokinase is not a replacement for prescription blood thinners or medical treatment. Always talk to your healthcare provider if you are on medication or have existing cardiovascular conditions.

How Nattokinase Works in Your Body

The short version

Nattokinase is a fibrinolytic enzyme originally discovered in natto, a traditional Japanese fermented soybean dish. It helps your body maintain healthy blood flow by supporting the natural breakdown of fibrin – a protein involved in clot formation.PMC+1

In plain language:

It helps keep your “blood highways” flowing more smoothly, which is essential for heart, brain, and whole-body health.

What the research shows

Emerging human and observational studies suggest that nattokinase may:

• Support healthy blood pressure

  • In one randomized, placebo-controlled trial, adults with elevated blood pressure who took 2,000 FU/day for 8 weeks saw modest reductions in systolic blood pressure vs placebo.Nature+1

• Improve lipid profile & arterial plaque measures at higher doses

  • A large human study (over 1,000 participants) using 10,800 FU/day for 12 months reported improved blood lipids and a reduction in measures of atherosclerotic plaque, with good tolerability.Frontiers+1

• Support overall cardiovascular health

  • Population research in Japan links regular natto consumption (the original food source of nattokinase) with reduced cardiovascular disease mortality.PMC+1

These findings are promising, but nattokinase is still a dietary supplement, not a drug. It should be used as part of a broader heart-healthy lifestyle (diet, movement, sleep, stress management) under the guidance of a healthcare professional.

What Makes Crane’s Nattokinase Blend Different?

Most nattokinase supplements offer enzyme only. Crane’s Nattokinase Blend is intentionally formulated with a Japanese, multi-ingredient approach:

1. 6,000 FU of Nattokinase per Serving

   • A meaningful dose for daily cardiovascular support rituals, building on clinical research that suggests higher FU intakes may be associated with more pronounced benefits in lipids and vascular markers.Frontiers+1

2. Synergy of Japanese-Inspired Ingredients

   • GABA – Helps support calm, relaxation, and healthy stress response, which is essential for heart health.

   • Aomori Garlic Extract – Traditionally used for cardiovascular, circulation, and immune support.

   • Okinawa Moromi Vinegar Extract – Fermented extract from Okinawan awamori production, associated with metabolic and circulatory support in Japanese tradition.

3. Japanese Heritage & Manufacturing

   • Developed based on decades of natto and nattokinase research in Japan.PMC+1

   • Produced in facilities compliant with strict Japanese quality standards and international GMP practices.

4. Thoughtful Formulation for Daily Use

   • Designed as a long-term ritual, not a quick fix.

   • Capsule format makes it easy to add to your nightly routine.

How to Take Nattokinase Blend

Suggested Use (General Adults)

Always follow your product label and talk to your healthcare provider for personal guidance.

• Serving: Typically 2 capsules per day (6,000 FU total)

• Timing:

  • Many people prefer to take nattokinase in the evening, when circulation naturally slows as you sleep.

• With or without food:

  • Often recommended on an empty stomach for optimal absorption of the enzyme.

Tips:

• Take it at the same time every day to build consistency.

• Pair it with a simple ritual (evening skincare, tea, turning off screens) so you don’t forget.

What Results Can You Expect?

Every body is different, and supplements work best as part of an overall heart-healthy lifestyle. But many people report:

In the First Few Weeks

• Feeling a bit lighter or less “sluggish” in legs and body

• Gradual changes in warmth of hands and feet

• A sense of doing something proactive for circulation and heart health

1–3 Months

• More noticeable shifts in stamina and daily energy, especially when paired with walking or gentle exercise

• Support for maintaining healthy blood pressure and lipids alongside diet & exercise, as seen in clinical research at daily doses of 2,000–10,800 FU.Nature+1

3+ Months

• Integration into a daily longevity routine – like brushing your teeth for your arteries

• Works best when stacked with movement, nutrient-dense foods, sleep, and stress management

Supplements support your body’s natural processes over time. Consistency is key – think in months and lifestyle, not days.

Who Should Not Take Nattokinase Blend?

Because nattokinase has effects on fibrin and clot-related pathways, it’s not appropriate for everyone.

You should avoid nattokinase or use it only under medical supervision if you:

• Are currently taking blood thinners, anticoagulants, or antiplatelet medications

• Have a history of bleeding disorders, hemorrhagic stroke, or serious clotting abnormalities

• Have an active peptic ulcer or uncontrolled bleeding risk

• Are scheduled for surgery (typically discontinue well before and after per medical advice) Drugs.com+1

• Are pregnant or breastfeeding, as safety data are limited Drugs.com+1

Safety reminder:
Always discuss nattokinase with your doctor or pharmacist, especially if you have cardiovascular conditions or take prescription medication.

Nattokinase Blend vs Other Options

Here’s a simplified comparison to help clarify where Crane’s Nattokinase Blend fits in your routine:

Important: Nattokinase (any brand) is not the same as prescription anticoagulants. Do not stop or change medications without medical guidance.

How to Get the Most Out of Nattokinase Blend

Nattokinase works best inside a complete heart-healthy lifestyle:

1. Move Daily

   • Aim for walking, light cardio, or stretching to encourage blood flow.

   • Even 10–15 minute “movement snacks” throughout the day help circulation.

2. Support Blood Pressure Naturally

   • Prioritize fruits, vegetables, and high-fiber foods.

   • Reduce ultra-processed foods and excessive sodium when possible.

3. Stay Hydrated

   • Proper hydration supports blood volume and circulation.

   • Pair your evening Nattokinase Blend with a glass of water or herbal tea.

4. Manage Stress & Sleep

   • Chronic stress and poor sleep can strain your cardiovascular system.

   • Combine Nattokinase Blend with calming evening habits (breathwork, journaling, Sleep Well Blend if appropriate, etc.).

5. Stack with Other Crane Rituals (Optional)

   • Tone & Glow Coix Seed Extract Powder: for skin + inner glow while you support circulation.

   • Pure Oceanic Root Iodine: supports thyroid and metabolism, complementary for an overall longevity plan (always confirm with your doctor).

   • Matcha Mushroom Latte or Zen Energy: gentler energy and antioxidant support for daytime.

Frequently Asked Questions About Nattokinase Blend

1. Is Nattokinase Blend a blood thinner?

Nattokinase supports the body’s natural ability to break down fibrin and maintain healthy circulation. Research suggests it has antithrombotic and fibrinolytic activity, but it is not a prescription blood thinner and should not be used in place of medications your doctor prescribes.MDPI

If you’re on anticoagulant or antiplatelet medications, or have a clotting/bleeding condition, talk to your healthcare provider before using it.

2. How long can I take Nattokinase Blend?

Human studies show nattokinase used safely for months to years at various doses, with good tolerability in healthy adults.PMC+1

However, because heart health is complex, it’s wise to re-check with your healthcare provider periodically and monitor any changes in your meds, conditions, or lab work.

3. How soon will I feel a difference?

Some people feel subtle changes (like less heaviness, warmer hands/feet, more ease with activity) within a few weeks, especially when combined with movement and healthier habits. Clinical improvements in certain blood markers or arterial measures in studies have typically been seen over 8–12 weeks or longer.Nature+1

Think of this as a long-term daily ritual, not an instant fix.

4. Can I take Nattokinase Blend with my current supplements?

In many cases, nattokinase can be combined with other supplements aimed at heart, energy, and longevity support, but interactions are always possible—especially with products that also affect blood flow or clotting.

You should definitely check with your healthcare provider if you’re taking:

• Omega-3s or high-dose fish oil

• Other circulation or “blood thinning” formulas

• Any prescription cardiovascular medications

5. Is Nattokinase Blend safe for people with high blood pressure or cholesterol?

Some clinical studies suggest nattokinase may help support healthy blood pressure and lipid profiles when combined with lifestyle changes.Nature+2Dove Press+2

However:

• It is not a replacement for prescribed blood pressure or cholesterol medication.

• Always involve your doctor if you have hypertension, high cholesterol, a history of heart disease, or are on related medication.

6. Is Nattokinase Blend vegan and allergen-friendly?

(Use your actual label details here.)

• Note capsule shell (vegan or not)

• Any major allergen info (soy traces due to natto, etc.)

• Free-from list (gluten, dairy, synthetic colors, etc. if applicable)

7. Can I take Nattokinase Blend if I’m pregnant or breastfeeding?

Because safety data in pregnancy and breastfeeding are limited, major references recommend avoiding nattokinase during these times.Drugs.com+1

Always consult your OB/GYN or pediatric provider before taking any supplement while pregnant or nursing.

8. What’s the difference between eating natto and taking Nattokinase Blend?

• Natto: Whole traditional food with nattokinase plus vitamin K2, fiber, and other nutrients. Taste & texture can be challenging, and nattokinase content varies by batch. Generally speaking, a normal serving of natto can have around 2,000FU in it. PMC+1

• Nattokinase Blend: Convenient, standardized enzyme dose (6,000 FU) plus synergistic ingredients like GABA, garlic extract, and moromi vinegar, without the natto flavor. This makes it a lot easier to get a larger dosage on a daily basis.

Many Japanese longevity routines rely on both: traditional foods + smart supplementation.

A Brief History of Natto & Nattokinase

To understand nattokinase, it helps to go back to its source: natto, a sticky, stringy, strongly flavored dish made from soybeans fermented with Bacillus subtilis natto. Natto has been eaten in Japan for hundreds of years, with written records tracing it back at least to the 11th century, and legends suggesting it may have been discovered accidentally when cooked soybeans were left to ferment in straw. Light Cellar+1

For generations, natto has been considered a kind of “food medicine” in Japan—associated with heart health, strong bones, and longevity. It’s naturally rich in vitamin K2, probiotics, and a fibrin-dissolving enzyme that would later be identified as nattokinase.Light Cellar+1

In the early 1980s, Japanese researcher Dr. Hiroyuki Sumi, working at the University of Chicago, was searching for natural substances that could help dissolve blood clots. In a now-famous experiment, he placed natto on an artificial fibrin (clot) in a petri dish and saw it dissolve the fibrin within hours. He isolated the active enzyme, named it “nattokinase” (“enzyme from natto”), and opened the door to decades of cardiovascular research. Physicians Preference Vitamins+3PMC+3Media Website CDN+3

Since then, studies have explored how both natto itself and purified nattokinase may support healthy blood flow, blood pressure, and cardiovascular outcomes. Population research in Japan suggests that higher intake of natto and fermented soy products is associated with reduced cardiovascular disease mortality and better longevity, which aligns with what Japanese culture has intuitively believed for generations. Dr.Oracle+4ScienceDirect+4PMC+4

Crane Wellness’ Nattokinase Blend builds on that heritage—capturing the circulatory-supportive power of nattokinase in a precise, daily dose, while layering in other Japanese-inspired ingredients for a modern, easy-to-take ritual.

Bringing It All Together

Healthy circulation touches everything: heart, brain, energy, mobility, and long-term vitality. Traditional Japanese diets have quietly supported this for centuries through foods like natto; modern science is now catching up to explain why these rituals work so well.

By taking Nattokinase Blend 6,000 FU daily, you’re:

• Supporting your body’s natural ability to maintain healthy blood flow

• Adding a simple, culturally-rooted habit to your longevity routine

• Giving yourself a small but meaningful way to show up for your future heart, every single day

Pair it with movement, hydration, nutrient-dense meals, and good sleep, and Nattokinase Blend becomes more than just a supplement—it becomes part of your daily commitment to aging well.

Ready to make healthy circulation part of your everyday ritual?
→ Add Nattokinase Blend 6,000 FU to your routine and start building better heart health, one day at a time.