Your heart is tirelessly working, pumping blood through approximately 60,000 miles of blood vessels every single day. Good circulation is crucial for delivering nutrients and oxygen throughout your body, supporting overall health, longevity, and vibrant energy. But did you know there's a powerful yet natural enzyme, used for centuries in Japan, that can significantly enhance circulation and protect your heart? Meet Nattokinase.
This comprehensive guide will introduce you to nattokinase, highlighting its benefits, the clinical research backing its efficacy, and how it might become a critical component of your heart-healthy routine.
What Exactly Is Nattokinase?
Nattokinase is a natural enzyme extracted from natto, a traditional Japanese food made from fermented soybeans. Natto has been consumed for centuries in Japan, celebrated for its distinct taste, high nutritional value, and remarkable health-promoting effects—especially regarding cardiovascular health and longevity.
At Crane Wellness, we've specialized in high-quality nattokinase supplements for over 25 years. Our deep roots in Japanese wellness traditions and our expertise in longevity and autophagy science set us apart, providing supplements you can trust for your lifelong wellness.
How Does Nattokinase Support Heart and Circulatory Health?

The primary reason nattokinase has garnered significant attention is due to its impressive ability to support healthy blood flow and reduce risks associated with cardiovascular health. Here's how it works scientifically:
1. Promotes Healthy Blood Flow and Circulation
Blood clots are a significant risk factor for cardiovascular events such as heart attacks and strokes. Nattokinase has been extensively studied for its fibrinolytic activity, meaning it can break down fibrin, a protein that causes clots.
Clinical Evidence:
A landmark study published in the journal Nutrition Research found that oral nattokinase supplementation improved blood flow in healthy individuals. Regular intake of nattokinase may therefore contribute significantly to improved overall cardiovascular health [1].
2. Supports Healthy Blood Pressure Levels
Nattokinase may naturally lower blood pressure. High blood pressure can cause damage to arteries and contribute to heart disease and stroke.
Clinical Evidence:
Research in Hypertension Research indicated that participants supplementing with nattokinase for eight weeks experienced a significant reduction in both systolic and diastolic blood pressure levels, demonstrating nattokinase's potential as a natural, complementary approach to blood pressure management [2].
3. Supports Healthy Cholesterol Levels
Nattokinase has also demonstrated potential in supporting healthy cholesterol profiles, particularly by improving HDL (good cholesterol) and reducing LDL (bad cholesterol).
Clinical Evidence:
A study in the Journal of Nutritional Science and Vitaminology observed that nattokinase supplementation contributed to improved cholesterol profiles and arterial health, suggesting a broader protective role for cardiovascular wellness [3].
4. Enhances Circulation by Reducing Blood Viscosity
Blood viscosity refers to the thickness and stickiness of your blood. Higher viscosity can slow down circulation, raising the risk of cardiovascular complications. Nattokinase supports blood fluidity by reducing viscosity and enhancing the smooth flow of blood throughout the body.
Clinical Evidence:
Research published in the Clinical Hemorheology and Microcirculation journal demonstrated nattokinase's ability to reduce blood viscosity, contributing to smoother circulation and reducing stress on the heart [4].
Traditional Wisdom Meets Modern Science
Nattokinase uniquely bridges traditional wisdom with modern scientific validation. Originally discovered in Japan by Dr. Hiroyuki Sumi in the 1980s, the nattokinase enzyme has now been extensively studied and validated across multiple scientific platforms worldwide.
Historically, Japanese communities with high natto consumption have notably lower incidences of cardiovascular diseases. This observation inspired researchers to explore nattokinase's potential therapeutic uses, uncovering remarkable health benefits that now benefit people globally.
Incorporating Nattokinase Into Your Wellness Routine

Supplementing your diet with nattokinase can be a straightforward addition to your routine:
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Dosage: Typical recommended dosage is around 2,000–6,000 FU daily, depending on current health status and needs. Always consult with your healthcare provider for personalized recommendations.
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Timing: Nattokinase is generally most effective when taken consistently, ideally once daily with meals or right before bed.
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Quality: Look for products that clearly list fibrinolytic units (FU)—an indicator of nattokinase potency. Crane Wellness’ Nattokinase Blend clearly specifies potency, purity, and quality standards.
At Crane Wellness, we’re passionate about longevity and holistic wellness, specializing in premium-quality nattokinase supplements backed by over two decades of experience. Our commitment to purity, potency, and science-based formulations ensures optimal effectiveness and safety.
Holistic Heart Health: Additional Recommendations
For maximum cardiovascular benefit, consider complementing nattokinase supplementation with these heart-healthy practices:
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Balanced Diet: Focus on heart-supportive nutrients such as omega-3 fatty acids, antioxidants from colorful fruits and vegetables, and fiber-rich foods.
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Regular Exercise: Moderate aerobic exercise (30 minutes/day) boosts circulation and heart function.
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Hydration: Drinking sufficient water daily supports smooth circulation and overall heart health.
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Stress Management: Practices like mindfulness, meditation, and yoga help manage stress and its impact on cardiovascular health.
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Sleep Quality: Adequate sleep is crucial for heart and metabolic health—aim for 7–9 hours per night.
Conclusion: The Path to Longevity Begins with Circulation
Supporting your circulation is a foundational pillar for overall longevity, heart health, and well-being. Nattokinase, rooted deeply in traditional Japanese wellness and now validated by modern science, offers a safe, effective, and holistic way to maintain and enhance heart health naturally.
At Crane Wellness, we're proud of our legacy in nattokinase research and product development, remaining committed to providing high-quality solutions grounded in both tradition and scientific innovation.
By making nattokinase a staple of your wellness regimen, you're investing in healthier circulation, longevity, and vibrant well-being for years to come.
References
[1] Nutrition Research, "Effect of nattokinase supplementation on blood flow and cardiovascular health," https://www.sciencedirect.com/science/article/abs/pii/S027153171600032X.
[2] Hypertension Research, "Antihypertensive effects of nattokinase," https://www.nature.com/articles/hr200831.
[3] Journal of Nutritional Science and Vitaminology, "Effects of nattokinase supplementation on cholesterol levels," https://pubmed.ncbi.nlm.nih.gov/19202234/.
[4] Clinical Hemorheology and Microcirculation, "Nattokinase effects on blood viscosity and circulation," https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch1768