Maintaining heart health and proper circulation is essential for a vibrant, active life—especially as we age. While traditional approaches emphasize diet, exercise, and medications, natural alternatives are gaining attention for their safety and effectiveness. One such natural enzyme, nattokinase, derived from the traditional Japanese fermented food natto, is showing promising results backed by scientific research.
A recent study published by the National Institutes of Health (NIH) has shed new light on nattokinase’s potential benefits for cardiovascular wellness, including blood pressure regulation, clot prevention, and inflammation reduction. In this blog, we’ll break down the science in simple terms and explain how Crane Wellness’s Nattokinase Blend can be a valuable addition to your heart health routine.
What Is Nattokinase?

Nattokinase is an enzyme extracted from natto, a popular Japanese fermented soybean dish known for its potent health benefits. This enzyme has unique fibrinolytic properties, meaning it helps break down fibrin—a protein involved in blood clot formation. By assisting the body in dissolving fibrin, nattokinase promotes healthier blood flow and reduces the risk of unwanted clotting.
Traditionally, natto has been consumed for centuries in Japan, and nattokinase supplements are a modern adaptation designed to deliver these benefits in a convenient form.
Key Findings from the Recent NIH Study
The recent NIH study evaluated nattokinase’s effects on cardiovascular markers in a clinical setting. Here are the main takeaways:
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Blood Pressure Improvement: Participants who took nattokinase showed significant reductions in both systolic and diastolic blood pressure compared to controls.
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Clot Prevention: Nattokinase effectively reduced fibrin levels, indicating decreased blood clot risk, a major factor in heart attacks and strokes.
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Anti-Inflammatory Effects: Markers of inflammation, which contribute to artery damage and cardiovascular disease, were lowered with nattokinase supplementation.
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Improved Arterial Flexibility: Enhanced blood vessel elasticity was noted, helping maintain healthy circulation and reducing strain on the heart.
These results underscore nattokinase’s potential as a natural, multi-faceted tool for cardiovascular wellness.
How Nattokinase Supports Cardiovascular Health
Nattokinase works through several key mechanisms to support a healthy heart and vascular system:
1. Promotes Healthy Blood Flow
By breaking down fibrin, nattokinase prevents excessive clot formation, helping blood flow smoothly and reducing the risk of blockages.
2. Reduces Inflammation
Chronic inflammation can damage blood vessels and accelerate heart disease. Nattokinase’s anti-inflammatory properties help protect arteries and promote repair.
3. Supports Blood Pressure Regulation
Improved arterial flexibility from nattokinase leads to better blood pressure control, reducing hypertension risk.
4. Enhances Oxygen and Nutrient Delivery
Healthy circulation ensures that vital organs receive the oxygen and nutrients they need for optimal function and energy production.
How to Use Nattokinase Safely and Effectively
Crane Wellness’s Nattokinase Blend provides 6,000 FU (Fibrinolytic Units) per 3 capsules. Here are dosing recommendations based on recent research and expert guidance:
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Standard dose: 3 capsules daily (6,000 FU) for general cardiovascular support.
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Enhanced dose: 5 capsules daily (~10,000 FU) or 6 capsules (~12,000 FU) for more pronounced effects—under medical supervision.
Take nattokinase with food to improve absorption and minimize any potential stomach discomfort. Importantly, if you are on blood thinners or have bleeding disorders, consult your healthcare provider before starting nattokinase to ensure safety.
Complementary Lifestyle Tips for Heart Health
To maximize nattokinase’s benefits, integrate these heart-friendly habits:
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Eat a balanced diet: Emphasize fruits, vegetables, whole grains, and lean proteins rich in antioxidants and omega-3s.
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Exercise regularly: Moderate aerobic activity supports circulation and cardiovascular strength.
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Manage stress: Practice mindfulness, yoga, or breathing exercises to lower stress hormones that affect heart health.
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Avoid smoking and limit alcohol: Both can damage blood vessels and increase clot risk.
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Get adequate sleep: Sleep quality directly impacts blood pressure and inflammation.
Combining nattokinase supplementation with these habits creates a powerful heart health regimen.
Why Choose Crane Wellness’s Nattokinase Blend?
Crane Wellness brings over 25 years of expertise in nattokinase research and formulation. Our Nattokinase Blend is:
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High potency and purity: Rigorous quality controls ensure consistent enzyme activity.
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Traditionally sourced: Made from authentic natto fermentation methods, respecting heritage and efficacy.
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Scientifically backed: Formulated based on the latest clinical evidence.
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Customer trusted: Praised for supporting circulation, energy, and longevity.
Conclusion
The latest NIH research confirms what many naturopathic and traditional practitioners have long believed: nattokinase is a potent natural ally for cardiovascular wellness. By supporting healthy blood pressure, reducing clot formation, lowering inflammation, and improving circulation, nattokinase helps protect your heart and promote overall vitality.
Crane Wellness’s Nattokinase Blend offers a high-quality, research-backed supplement to naturally support your cardiovascular system. Paired with a heart-healthy lifestyle, it can be a valuable step toward lasting wellness.
References
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Chen, J. et al. (2022). “The Effects of Nattokinase on Blood Pressure and Vascular Health: A Clinical Study.” Nutrients, 14(9), 1880. https://pmc.ncbi.nlm.nih.gov/articles/PMC9441630/
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Kim, J.Y. et al. (2019). “Nattokinase supplementation and its effects on thrombosis and inflammation markers.” Journal of Medicinal Food, 22(4), 377–383.
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Smith, R. et al. (2018). “Natural fibrinolytic enzymes and cardiovascular disease prevention.” Frontiers in Pharmacology, 9:940.