For centuries, natto—a traditional Japanese food made from fermented soybeans—has been revered in Japan for its nutritional value and unique health benefits. But in recent years, one compound in particular has gained attention from researchers and integrative health experts alike: nattokinase, a powerful enzyme produced during the fermentation of natto.
Nattokinase is especially valued for its cardiovascular support, and is the star ingredient in Crane Wellness’ Nattokinase Blend. Here's why health professionals are increasingly recommending it as part of a modern heart health routine.
1. Supports Healthy Circulation by Breaking Down Fibrin
Nattokinase has been shown to break down fibrin, a protein involved in blood clot formation. When fibrin accumulates, it can contribute to poor circulation and increased cardiovascular risk.
In one clinical study, nattokinase supplementation was found to reduce fibrinogen levels by 9–15% over an 8-week period, promoting smoother blood flow and reducing the risk of clot-related issues (Atherosclerosis, 2008).
This makes it particularly helpful for individuals who live a sedentary lifestyle, travel often, or are looking to naturally support blood flow and vessel health.
2. Naturally Helps Regulate Blood Pressure
Several studies have shown that nattokinase may help lower systolic and diastolic blood pressure. In a double-blind, placebo-controlled trial involving 86 subjects with elevated blood pressure, nattokinase supplementation resulted in a significant drop in both systolic and diastolic readings over 8 weeks (Hypertension Research, 2008).
Experts believe this effect is linked to nattokinase’s ability to promote vasodilation (relaxation of blood vessels) and improve circulation.
3. Promotes Arterial Elasticity and Vascular Health
Healthy arteries are flexible and resilient—but age, stress, and poor diet can stiffen them. Nattokinase has been studied for its role in supporting vascular elasticity, which is essential for maintaining stable blood pressure and overall cardiovascular function.
By improving the breakdown of blood clots and reducing inflammation, nattokinase may help keep arteries more supple and reduce the risk of plaque formation (Scientific Reports, 2015).
4. May Reduce Risk of Cardiovascular Events
Researchers have found a correlation between higher nattokinase intake and a lower risk of cardiovascular events like stroke and heart attack. A 2017 review in Frontiers in Bioscience emphasized nattokinase’s potential to act as a natural antithrombotic agent, offering benefits similar to pharmaceutical blood thinners—but without the associated side effects for most users.
While more long-term research is needed, many health professionals consider nattokinase a promising addition to heart health protocols.
5. Supports Healthy Aging and Longevity
In Japan, where natto is a staple food, cardiovascular disease rates are notably lower than in many Western countries. Nattokinase is believed to be one of the contributing factors to the longevity of Japanese populations, particularly in Blue Zones like Okinawa.
Its ability to promote circulation, reduce clotting risk, and support vascular health makes it a favorite among integrative doctors focusing on graceful, healthy aging.
Bonus: Emerging Research Shows Promise for Respiratory Health
Recent studies suggest that nattokinase may support respiratory health by thinning mucus and reducing inflammation in the sinuses and lungs.
According to WebMD and early research, nattokinase has shown potential in shrinking nasal polyps and easing sinus blockages. It is currently being studied as a possible adjunct therapy for chronic sinusitis, COPD, and bronchitis due to its mucolytic and anti-inflammatory effects.
Final Thoughts
Nattokinase is more than just a traditional food enzyme—it’s a clinically studied, science-backed compound with wide-reaching benefits for cardiovascular and circulatory health. Whether you’re focused on blood pressure, circulation, or overall vitality, Crane Wellness’ Nattokinase Blend offers a powerful, natural way to support your heart.
