Your Guide to Nattokinase Science and Benefits
Discover the Japanese Longevity Secret
Nattokinase is a powerful enzyme derived from Natto, a traditional Japanese fermented soybean dish celebrated for centuries.
Renowned for its ability to support cardiovascular health and circulation, Nattokinase combines traditional wisdom with modern scientific validation to deliver significant wellness benefits.

What is Nattokinase?
Nattokinase is an enzyme extracted from Natto, created through the fermentation of soybeans by the beneficial bacteria Bacillus subtilis.
Originating in Japan over 2,000 years ago, Natto has been a staple in traditional Japanese diets, widely regarded for promoting longevity and robust health due to its unique enzyme profile.

Key Benefits of Nattokinase
Cardiovascular Support:
- Promotes healthy blood flow and circulation.
- Helps maintain optimal blood pressure levels.
- Exhibits natural blood-thinning properties, aiding in the prevention of clots.
- Supports cardiovascular health by enhancing circulation.
- May aid in reducing unhealthy cholesterol, contributing to overall cardiovascular wellness.
- Helps reduce inflammation throughout the body.
- Provides antioxidant protection, reducing oxidative stress.
- Supports respiratory health by improving circulation and reducing inflammation in lung tissues.
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How to Use Nattokinase
To maximize health benefits, take Nattokinase regularly:Typical dosage: 100 mg or 2,000 FU (Fibrinolytic Units) daily for preventative care. Most studies show that at least 4,000 FU per day should be taken to see improvements on heart, artery, blood pressure, endometriosis and more.
Best consumed on an empty stomach for optimal absorption.
Best time is generally at night, when your circulation naturally slows down.
Consistency is key. Incorporate into your daily wellness routine.
Most people start seeing a difference in 2-6 weeks, depending on current health.

Scientific Research & Clinical Studies
Nattokinase’s benefits are extensively supported by research:
- A 2017 clinical trial published in Scientific Reports demonstrated that daily supplementation with Nattokinase significantly improved circulation and reduced risks associated with blood clots.
- Research from the International Journal of Molecular Sciences (2021) highlights Nattokinase’s potent fibrinolytic (clot-dissolving) capabilities, supporting its use in promoting cardiovascular health.
- Additional studies in the Journal of Nutrition and Food Sciences have underscored its beneficial effects on cholesterol management and overall cardiovascular wellness.

Why Choose Crane Wellness Nattokinase Blend
Crane Wellness provides premium-quality Nattokinase:
- Expertly extracted to ensure high potency (6,000 FU per serving).
- Includes Garlic Extract, GABA, and Okinawa Moromi Vinegar for added potency
- Non-GMO, sustainably sourced, and purity tested.
- Produced through advanced fermentation techniques, maintaining the highest quality standards since 1974.
DIVE IN TO MORE ABOUT NATTOKINASE

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Read MeFAQs About Nattokinase
Can I take Nattokinase with other medications?
Consult your healthcare provider before combining Nattokinase with anticoagulants or other medications.
Is Nattokinase suitable for vegetarians and vegans?
Yes, Nattokinase sourced from fermented soybeans is completely plant based. It is also gluten free!
When is the best time to take Nattokinase?
Generally, before bed is the best time to take Nattokinase, but it can be taken anytime of day or both morning and night, depending on your needs.
Who should not take Nattokinase?
- Individuals with bleeding disorders or those taking blood-thinning medications should avoid nattokinase supplements without medical supervision.
- Pregnant and breastfeeding women, as well as children and adolescents, should avoid nattokinase due to a lack of sufficient safety data.
- Individuals with a history of deep vein thrombosis should consult with a healthcare professional before considering nattokinase.
How much do I need to use to start seeing results? How long will it take?
Most people start seeing results in the first 2-4 weeks, with improvements building over the 4-8 week period. Depending on your health, this can vary.