As much as we may not want to admit it, aging is a natural process. But with the right support, we can age gracefully and maintain our active lifestyles. Science has identified several ingredients that promote healthy aging by supporting skin health, cellular function, and overall well-being. Here's a curated list of ten science-backed ingredients to help you on your journey to radiant longevity.
1. Coix Seed Extract – Hydration & Skin Clarity
Coix seed, also known as Job's tears, is a traditional Japanese ingredient renowned for its skin benefits. Rich in antioxidants and anti-inflammatory compounds, it supports skin hydration and clarity. Studies have shown that coix seed extract can improve skin texture and reduce blemishes. It has also been shown to improve gut health (which impacts brain function, particularly in our senior years) and joint health - which we all know worsens over time (can I have good knees over 50? I hope so!).
Crane Product: Tone & Glow Coix Seed Extract Powder
2. Astaxanthin – Potent Antioxidant for Skin Health
Astaxanthin is a powerful antioxidant derived from microalgae. It has been shown to improve skin elasticity, reduce wrinkles, and protect against UV-induced damage. A study published in the Journal of Cosmetic Dermatology found that astaxanthin supplementation improved skin hydration and elasticity in women aged 30-60.
Recommended Product: Nutrex Hawaii BioAstin
3. Nattokinase – Circulation & Cardiovascular Support
Nattokinase, an enzyme extracted from fermented soybeans, supports healthy blood flow and cardiovascular function. Improved circulation ensures that nutrients and oxygen are efficiently delivered to the skin and other organs, promoting overall vitality.
Crane Product: Nattokinase Blend
4. Curcumin – Anti-Inflammatory & Antioxidant Powerhouse
Curcumin, the active compound in turmeric, possesses strong anti-inflammatory and antioxidant properties. It has been shown to reduce oxidative stress and inflammation, both of which contribute to aging. A review in the journal Molecules highlighted curcumin's potential in delaying age-related diseases.
Recommended Product: Thorne Curcumin Phytosome 1000mg
5. Marine Collagen Peptides – Skin Firmness & Elasticity
Collagen is essential for maintaining skin structure and elasticity. Marine collagen peptides are easily absorbed and have been shown to improve skin hydration, elasticity, and reduce wrinkles. A study in the Journal of Cosmetic Dermatology demonstrated significant improvements in skin elasticity after collagen supplementation. Study link: pmc.ncbi.nlm.nih.gov
Crane Product: Radiant Renew Collagen Hydration Complex
6. Resveratrol – Cellular Longevity & Mitochondrial Support
Resveratrol, a polyphenol found in grapes and berries, activates sirtuins—proteins associated with longevity. It supports mitochondrial function and has antioxidant properties. Research in the journal Frontiers in Genetics indicates that resveratrol can positively influence lifespan and healthspan.explorationpub.com
Recommended Product: Toniiq Ultra High Purity Resveratrol
7. Adaptogenic Mushrooms & Green Tea Polyphenols – Stress Resilience & Antioxidant Support
Adaptogenic mushrooms like reishi and lion's mane, combined with green tea polyphenols such as EGCG, enhance the body's resilience to stress and provide antioxidant benefits. These compounds support immune function and protect against oxidative damage.
Crane Product: Matcha Mushroom Latte
8. Fucoidan (from Kelp) – Immune Modulation & Cellular Health
Fucoidan, a sulfated polysaccharide found in brown seaweed, has been shown to modulate the immune system and promote cellular health. It supports the body's natural defense mechanisms and may contribute to healthy aging.
Crane Product: Pure Oceanic Root Iodine
9. Nicotinamide Mononucleotide (NMN) – NAD+ Booster for Cellular Energy
NMN is a precursor to NAD+, a coenzyme vital for cellular energy production and DNA repair. Supplementation with NMN has been shown to increase NAD+ levels, enhancing mitochondrial function and potentially slowing age-related decline. A study in Cell Metabolism reported that NMN supplementation improved various physiological functions in aged mice.
Recommended Product: ProHealth NMN Selection
10. Omega-3 Fatty Acids – Inflammation Reduction & Skin Health
Omega-3 fatty acids, particularly EPA and DHA, are known for their anti-inflammatory properties. They support heart health, cognitive function, and skin integrity. Research in the Journal of the American Medical Association found that higher omega-3 levels were associated with slower telomere shortening, a marker of cellular aging.
Recommended Product: Sports Research Vegan Omega 3

Conclusion
Incorporating these science-backed ingredients into your daily routine can support healthy aging, enhance skin vitality, and promote overall well-being. Crane Wellness offers several products formulated with these powerful ingredients, rooted in Japanese wellness traditions and backed by modern science.
References
-
Journal of Cosmetic Dermatology: Astaxanthin supplementation improves skin hydration and elasticity.studypages.com+1centerwatch.com+1
-
Molecules: Curcumin's potential in delaying age-related diseases.
-
Frontiers in Genetics: Resveratrol's influence on lifespan and healthspan.frontiersin.org+1academic.oup.com+1
-
Cell Metabolism: NMN supplementation improves physiological functions in aged mice. nature.com pmc.ncbi.nlm.nih.gov
-
Journal of the American Medical Association: Omega-3 levels associated with slower telomere shortening.